enzyme-catalysed conjugations of glutathione with unsaturated compound doi Glutathione-Mediated Conjugation Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Enzymatically catalyzed molecular aggregation |

2015;10:e0145383

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(2012) demonstrated that long-term exposure to CP impaired autophagy leading to CP resistance, and interestingly, upregulation of autophagic response under such condition re-sensitized resistant cells to CP-induced cell death

Common observations include a reduction in certain beneficial genera (such as butyrate producers Roseburia and Faecalibacterium ) and an increase in pro-inflammatory genera (like Escherichia or Oscillospira in some reports) [213]