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In both trials, Reclast demonstrated a superior and more rapid therapeutic response compared with risedronate and returned more patients to normal levels of bone turnover, as evidenced by biochemical markers of formation (SAP, serum N-terminal propeptide of type I collagen [P1NP]) and resorption (serum CTx 1 [cross-linked C-telopeptides of type I collagen] and urine -CTx)

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The experiments with the ESCs also illuminated the fact that PDFV increases migration and invasion of ESCs

doi:10.1007/s10620-008-0332-9 34

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