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-------------------------------------------------------------------------------- 1 Based on a maximum recommended amitriptyline dose of 150 mg/day or 3 mg/kg/day for a 50 kg patient

For one, we used the MitoQC mouse, an animal enabling strong, direct in vivo evidence of mitophagymitochondria have green and red fluorescence that turns to red fluorescence alone when the mitochondrion is engulfed in a lysosome (McWilliams et al., 2016)

This natural reduction in collagen affects not only our physical appearance, such as decreased skin elasticity, but also the functional integrity of our joints and muscles

Glutathione restricts serine metabolism in regulatory T cells (Tregs), maintaining their suppressive capacity and preventing autoimmune responses

Authors contributions Conception and design of the manuscript, and interpretation of data (SR, PB), acquisition of data and performing of experiments (SR, KP, MY, JP, PW, QS, PB), and revising the manuscript for important intellectual content (SR, FD, PB)