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First, since this is a narrative review rather than a systematic review, the selection of studies evaluated in this review may have introduced biases due to the limited availability of research articles on certain aspects of the topic

Certain groups are more prone to B12 deficiency, including older adults, individuals with gastrointestinal conditions (such as Crohns disease or celiac disease), those who have undergone gastric surgery, or people with dietary restrictions

doi: 10.1093/jnci/94.17.1301 285

Because both medications slow gastric emptying, they can cause nausea, vomiting, and digestive discomfort