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Metformin reversed the obese state and alleviated airway inflammation and remodeling, with increased Tregs and related transcription factors in HFD- and OVA-induced airway sensitization (Al-Qahtani et al

The average duration of treatment was 15 weeks (range 1020), with peak levodopa equivalent daily doses (LEDD) reaching 702 mg

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Moreover, emerging evidence indicates that CNMs can be fermented by gut bacteria into bioactive metabolites like butyrate, which then modulate host physiology, such as intestinal stem cell differentiation highlighting not only toxicological but also transformative microbialhost interactions ( in vitro systems such as gut-on-chip platforms are increasingly integrated into tiered risk frameworks to enhance hazard identification without excessive animal use

XuXOcanseyDPeiBZhangYWangNWangZet alResveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis