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The presence of ribosomes, cellular compartments responsible for protein translation and maturation, distinguishes the rough ER, which then fuse into transitional and smooth ER structural domains that perform a variety of essential cellular functions and play important roles, including protein folding, modification, export, regulation of cytosolic calcium homeostasis, lipid metabolism and cholesterol synthesis (165, 166)

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It has been demonstrated that aged erythrocytes are especially prone to eryptosis associated with oxidation-induced PS exposure [72]

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