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Combination approaches that couple GSH-triggered release with ferroptosis induction, immunotherapy, radiotherapy, or metabolic modulation represent promising strategies to overcome resistance Fig

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Glutathione Is Essential in a Broad Range of Metabolic Processes Glutathione acts to neutralize a toxic metabolic byproduct: Methylglyoxal Glutathione is involved in the protein disulfide bond rearrangement that is necessary for the synthesis of one-third of the bodys proteins It protects the body from the oxidative damage caused by glutathione peroxidase by acting as a helper molecule for certain enzymes The liver uses Glutathione to help detoxify fats before the gallbladder emits bile, supporting healthy digestion Detoxification: Glutathione may also be crucial in the removal and detoxification of carcinogens, and according to recent studies, alterations in this metabolic pathway can influence cell survival profoundly

Characterized by memory and cognitive impairment in aging populations, it poses a significant health challenge