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Always document these comorbidities and manifestations they help justify lab tests, imaging, and extended visits

Role of IGF-1 in Neuroinflammation and Cogniton Deficits Induced by Sleep Deprivation

Diabetes Care 42 , 731754 (2019)

This group also synthesized and identified a far more potent ISA derivative, Derivative 10 (Figure 2J) ((3R, 4R, 6R, 8R, 9R)-8-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl 4,6-dichloronicotinate), which inhibits NLRP3 with an IC 50 of 0.29 M (Zhao et al., 2024)