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Adding cagrilintide at a moderate dose (1.0-2.4 mg) provides amylin-mediated appetite suppression through a completely different neuronal circuit, which may allow you to use a lower retatrutide dose (8 mg instead of 12 mg) while achieving comparable or superior total metabolic effect

Data from clinical studies have also shown that renal impairment in patients with overweight or obesity does not impact the pharmacokinetics of tirzepatide [see Use in Specific Populations (8.6)]

Guttman-Yassky E et al

The original packaging helps shield the medication from light, which can break down the peptide proteins over time and reduce its effectiveness