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doi: 10.1016/j.cortex.2013.11.009

Two mortalities were recorded in the highest (5000 mg/kg) and medium (2900 mg/kg) dose groups after 24 hours, but none were recorded in the lowest (1600 mg/kg) dose group

By downregulating NF-B and increasing Nrf2 activation, the entkauranoid diterpenoid glaucocalyxin-B, which is produced from Rabdosia japonica, was demonstrated to decrease oxidative stress and inflammation in a PD rat model caused by LPS [119]

[35] Drugs [edit] The anti-diabetic medication pioglitazone was shown in a mouse model of ALD to be effective at treating the metabolic effects of ALD, including metabolic failure and increased oxidative stress