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Preliminary single-cell RNA and ATAC-seq chromatin profiling of synovial fibroblasts from the TNF transgenic mouse model indicated that development of TNF--driven arthritis primes the emergence of distinct pathology-associated synovial fibroblasts subtypes and revealed key transcription factors such as Bach1 and Runx1 to drive arthritogenesis [32]

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however, if its happening on a regular basis and is accompanied by additional symptoms, it may indicate a more serious medical emergency