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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history

Type of nerve pain : Research suggests varying degrees of effectiveness for B12 depending on the specific type of nerve pain

However, its important to note that B12 injections can have side effects, although these are generally rare

Do I need a consultation before a B12 injection

Like Methionine, obesity and insulin resistance are thought to be strong activators of mTOR