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Mechanism of Action IGF-1 DES exerts its anabolic and metabolic effects through high-affinity binding to and activation of the IGF-1 receptor (IGF1R), a receptor tyrosine kinase that is widely expressed across virtually all cell types in the body and serves as the primary mediator of IGF-1's growth-promoting, anti-apoptotic, and metabolic actions

The cumulative impact of these processes results in the gradual loss of neuronal structure and function, manifesting as cognitive decline, motor impairments and other degenerative symptoms associated with NDs

To enhance the reliability of the results, inhibitors and activators were incorporated

Brain transporters for D-serine have recently been described

doi: 10.1371/journal.ppat.1005408 129 PriceCTAbu KwaikY