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doi: 10.3389/fnagi.2023.1152626

K.HarbourtD

Chronic obstructive pulmonary disease (COPD) induces dynamic hyperinflation, increases intrathoracic pressure (ITP) and PVR, compresses the LV and reduces stroke volume via direct ventricular interaction (DVI), a mechanical constraint worsened by the loss of elastic recoil in emphysema