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221 YoshiokaA.YamayaY.SaikiS.KanemotoM.HiroseG.BeesleyJ.et al (2000)

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The pathological changes could also include altered brain metabolism, excitotoxicity, free radical generation, neuroinflammation, blood-brain barrier dysfunction, and apoptosis

Over three decades ago, John Bienenstock proposed the concept of a common mucosal immune system, suggesting that the mucosal immune system itself is an organ where mucosal immune cells distributed throughout the body can interact across different mucosal tissues and organs 55

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