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These data are still very encouraging to be investigated with other experimental and clinical studies, especially in aged patients where the hepatic SIRT1 and circulating levels of DHEA are significantly decreased

Even with oral supplementation, deficiencies may persist due to reduced intrinsic factor or altered digestion

Water, Glycerin, Caprylic/Capric Triglyceride, Butylene Glycol, Methylpropanediol, Niacinamide, Tranexamic Acid, Dipropylene Glycol, Phenyl Trimethicone, 1,2-Hexanediol, Butyrospermum Parkii (Shea) Butter, Cetearyl Alcohol, Dicaprylyl Carbonate, Polyglyceryl-2 Stearate, Polysorbate 60, Glyceryl Stearate, Stearyl Alcohol, Sorbitan Sesquioleate, Sodium Polyacrylate, Stearic Acid, Lactose, Ammonium Acryloyldimethyltaurate / VP Copolymer, Microcrystalline Cellulose, Palmitic Acid, Betaine, Caprylic/Capric Triglyceride, Ethylhexylglycerin, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Propanediol, Allantoin, Adenosine, Polyisobutene, Tocopherol, Hydrogenated Lecithin, Disodium EDTA, Astaxanthin, CI 77491, Tocopheryl Acetate, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Arachidic Acid, Caprylyl / Capryl Glucoside, Sorbitan Oleate, Ceramide NP, Eriobotrya Japonica Leaf Extract, Theobroma Cacao (Cocoa) Extract, Myristic Acid, Oleic Acid, Glutathione, Hydroxypropyl Methylcellulose, Mentha Viridis (Spearmint) Extract, CI 14700, Ascorbic Acid, Sodium Hyaluronate, Dextrin

Study Design: during the 3-week study, 16 participants consumed 150 grams of goats milk fermented with Lactobacillus fermentum ME-3 (test group) while 5 participants ingested 150 g fresh goats milk without probiotics (control group)

MOTS-c adds meaningful benefit at this level because cellular energy efficiency becomes a limiting factor when dietary deficit is already dialed in