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10.1016/j.abb.2017.08.014 17

In addition, compared with the paraquat group, the mRNA expression of COL1A1, COL4A1 and -SMA in mice treated with thymoquinone decreased in a dose-dependent and time-dependent manner, indicating that thymoquinone can inhibit the activation of pro-fibrotic genes and extracellular matrix deposition