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The study used isolated natural killer cells from long Covid patients and healthy controls to determine the effect of LDN on TRPM3 ion channels.[ref] Genetic variants in TRPM3 are associated with response to LDN

Alvarez S, Roy Choudhury S, Sivagnanam K, Hicks LM, Pandey S (2015) Quantitative proteomics analysis of Camelina sativa seeds overexpressing the AGG3 gene to identify the proteomic basis of increased yield and stress tolerance

These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity

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Anand S, Pandey P, Begum MY, Chidambram K, Arya DK, Gupta RK, Sankhwar R, Jaiswal S, Thakur S, Rajinikanth PS