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Mechanism 2 Oxidative Stress Cigarette smoke contains over 4,000 chemical compounds, including potent free radicals reactive oxygen species (ROS) that damage cell structures

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for Spud cigarettes TIME Magazine November 9, 1931 *In our recent survey among Americas 2,000,000 Spud smokers, we found hundreds who light a cigarette the minute they wake up

The tobacco may be wrapped in paper, which makes it a type of cigarette

[83] The WHO states that "[m]uch of the disease burden and premature mortality attributable to tobacco use disproportionately affect the poor"