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B cells The overall number of B cells remains relatively stable throughout most of human lifespan, with a decline only observed in advanced old age, long after the initial signs of immune system inefficacy become apparent [345, 346]

Although this preliminary finding is promising, the vaccine concept should be explored in a more suitable model like in mice that are transgenic for both human FcRn and human IgG 25,57

www.aaojournal.org, dos Reis Neto, Edgard Torres, et al

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1 Introduction Aflatoxins (AFTs), di-furanocoumarin metabolites, accumulate in food and fodders due to contamination with Aspergillus flavus and Aspergillus parasiticus strains ( The toxicity of AFTs is principally due to their metabolism to a more toxic metabolite, namely, aflatoxin-exo-8,9-epoxide (AFTO) through hepatic cytochrome-P450 biotransformation ( There is ample proof indicating the embroilment of oxidative stress, inflammatory responses, and apoptotic pathway in AFT-induced nephrotoxicity ( Chlorella vulgaris [Chlorellaceae