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162 In a related approach, MMT was modified with copper ions to further enhance its therapeutic efficacy for IBD treatment

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ChIP analysis of posttranslational modifications of histones associated with genes that are active or poised for transcriptional activation, including H3K4me3, H4Ac, H3K27Ac and H3K4me1 marks 30 indicated the chromatin status of the IL-6 genomic locus in freshly isolated neutrophils to be inactive, whereas in autologous monocytes the status appeared already poised for transcription and more prone for rapid chromatin remodelling