cysteine and glutathione deficiency π§ͺ Depletion Pathways 1. Precursor Depletion - Key bottleneck: availability. - Source: Diet or hepatic transsulfuration ( methionine β homocysteine β cysteine) Inborn errors in the metabolism
Inborn errors in the metabolism of glutathione Orphanet Journal of Rare Diseases Springer Nature Link Glutathione synthesis ScienceDirect Glutathione synthetization MedLink Neurology A potent alternative cysteine production pathway allows reductase independence Nature Chemical Biology Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
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