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doi: 10.3389/fcell.2022.840171 175 HuangJYLuuHNButlerLMMidttunUlvikAWangRet al

However, in pathological conditions such as HF, this delicate balance falters, triggering a cascade of disruptions that ripple across organ systems

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Second, being a potent antioxidant, NAC may exert direct effects on some reactive oxygen species (ROS), whereas it is a precursor of cysteine (an essential substrate for glutathione synthesis) and also regulates the redox state by maintaining the thiol pool [20]