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Description

Lu K, Li HY, Yang K, Wu JL, Cai XW, Zhou Y, et al

H.KimH.KiH.YangI.YangN.LeeK

10.1038/nri3430 32 KangE

This system provides sequential therapeutic action: the DNA component acts as an early scavenger of damaging ROS, while the subsequently active aptamer competitively binds C5a, thereby inhibiting complement activation and downstream inflammatory amplification during later stages of IRI [68]