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10.1038/s41577-019-0165-0 69

Biochim Et Biophys Acta (BBA) - Mol Basis Disease

KYNA negatively correlated with depression severity and significantly increased after therapy [170]

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Additionally, when directed toward mitochondria and betaine synthesis, choline serves as a methyl donor for histone and protein methylation, key processes that regulate gene expression and cellular activity