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From Our Lecture Notes: The hypothalamus acts as the master hormonal regulator , influencing stress, hunger, reproduction, and circadian rhythm

This includes your skin, too

Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations

Bersten, D

In the case of malignant nodules, thyroidectomy is performed, followed by the administration of radioactive iodine to destroy any residual thyroid tissue, which may induce permanent hypothyroidism