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Branchedchain ketoacids secreted by glioblastoma cells via MCT 1 modulate macrophage phenotype

& Yin, L

Key Points One-carbon metabolism integrates cellular nutrient status by cycling carbon units from amino acid inputs to generate diverse outputs, including redox maintenance and cellular biosynthesis

A componenttarget network was constructed and visualized using Cytoscape software, consisting of 238 nodes (11 compounds and 30 genes) and 237 interaction edges (Fig