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doi: 10.3390/ani14131932 202 FrumentoDlu

The results showed that CRC DTP cells exhibited reduced sensitivity to the modeling drugs, and were reversible, quiescent, and specifically sensitive to ferroptosis induced by GPX4 inhibitors due to the upregulated GPX4 and ferrous iron

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It has also been shown that BH4 deficiency, due to the lack of SPR activity, resulted in impaired mitophagy, a process required to maintain the quality and quantity of healthy mitochondria [124]

In this study, we systematically examined the physiological roles of Mtr in response to oxidative stress by overexpressing the mtr gene in C