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Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Lpez-Glvez N, Wagoner R, Canales RA, Ernst K, Burgess JL, de Zapien J, et al

In patients with CBS deficiency, the treatment with a low-Met diet and betaine is highly recommended to maintain plasma Hcy concentration below 120 mol/L [231]

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In 2017, Murata and collaborators reported that serum carnitine level was negatively correlated with severity of constipation in 27 patients