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Blood 105 , 47434748 (2005)

10.1038/nsb789 [DOI] [PubMed] [Google Scholar] Tsui WC, Fersht AR

Periventricular leukomalacia Periventricular leukomalacia (PVL) is a diffuse damage of the cerebral white matter that extends beyond the periventricular regions found predominantly in preterm infants

Consequently, the patient experiences a significant decrease in the international normalized ratio, placing them at increased risk for thrombotic complications such as mechanical valve thrombosis unless the warfarin dose is appropriately escalated

There is currently no established protocol for administering 5-amino-1MQ capsules