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Notably, all the docked poses demonstrated substantial intermolecular contacts formation with essential residues (His 61 , His 85 , His 94 , His 259 , and His 263 ) and binuclear copper active site in the mh-Tyr enzyme (Table S1, Fig

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Exogenous sepiapterin can be reduced in all cells by sepiapterin reductase to 7,8-dihydrobiopterin (BH2) and further by DHFR to form BH4, known as the Salvage Pathway that has been exploited by many investigators as an approach to increase BH4 levels by pharmacological supplementation of sepiapterin

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Therefore, focusing on mechanisms contributing to cognitive decline in aging and identifying solutions to improve or reverse ACD will (a) have benefits for improving cognitive health in older adults, and (b) could identify potentially viable mechanistic clues for understanding and combating AD and dementia, especially because both aging and AD share several common associations