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PRDX1, 2 and 6 are mainly localized in the cytosol, while PRDX3 is present in the mitochondria, and PRDX4 is found in the endoplasmic reticulum and is also localized in the extracellular space

Conversely, large prospective cohorts and population-based studies, like for the past population studies, present more nuanced findings, with some reporting no association, possibly due to healthy worker effects, differential exposure misclassification, or lack of detailed shift characteristics

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10.1016/j.drup.2007.01.003 30 MakK

doi: 10.1016/j.freeradbiomed.2018.12.011 21 SabatierMBirsenRLautureLMoucheSAngelinoPDehairsJet al