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Thus, designing an all-rounder with space-time ROS scavenging, modulation of macrophage polarization, and promotion of angiogenesis and cell proliferation is a prominent subject for advancing the clinical treatment of chronic diabetic wounds

This adaptability enables macrophage polarization, which is the process by which macrophages mount a specific phenotypic and functional response to the microenvironmental stimuli encountered in a specific tissue (Sica and Mantovani, 2012)

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