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EF24, a notable derivative of curcumin, has been demonstrated to increase PTEN expression and subsequently inhibit the NF-B pathway (Table 1)

Be sure to: Buy broth that is organic and made from pasture-raised animals or wild-caught fish (this minimizes the toxins and maximizes the nutrients you get from the bone broth)

Wolfe, A

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The consensus is that supplemental GABA doesnt cross the blood-brain barrier well, so it may not raise brain GABA directly