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Choline supports liver function and is critical for transporting lipids out of the liver

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Similarly, in the enteric nervous system, the loss of neurons is replenished by neurogenesis precursor cells that behave like stem cells and are prominent in the submucosal zone and in the muscular layers ( in vitro, that a selective estrogen receptor (ER) agonist, LY3201, stimulated glial-to-neuron cell differentiation

Additionally, purines function as metabolic signals and play crucial roles in the central nervous system, particularly in the functioning of neuronal and glial cells (Fumagalli et al., 2017)

Clustering of samples by age was observed (Supplementary Fig