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Furthermore, extensive research suggests that OS may impact cognitive function through various pathways, such as directly damaging parvalbumin-expressing interneurons (PVIs) (Schiavone et al., 2009), hindering oligodendrocyte precursor cell (OPC) proliferation and myelin formation in the prefrontal cortex (PFC) (Maas et al., 2021), disrupting the bloodbrain barrier (BBB) (Geng et al., 2023), and inducing mitochondrial dysfunction (Fizikova et al., 2023)

SCFAs can induce the expression of indoleamine 2,3-dioxygenase 1 and aldehyde dehydrogenase in DCs, enhancing their induction of Treg differentiation

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doi: 10.3390/app13010610 109