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Role of ferroptosis in PD Ferroptosis is regulated by multiple interconnected pathways, including the GPX4/GSH system, iron and lipid metabolism, the NRF2 signaling pathway and mitochondrial function, in PD (Fig

Overall, further research is necessary to establish the stability of the models in terms of consistency and reproducibility

doi: 10.1016/j.biopha.2019.109767 229 KatelanSKonjevodaSSaricAUrlicILovricICanovicSet al

the third is Nano-Se can activate Nrf 2 signal transduction pathway to express genes related to antioxidant enzymes

An MTHFR mutation refers to changes in the MTHFR gene, which impact the enzyme's ability to convert folate to methylfolate efficiently