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A more general mechanism to explain oxidative stress generated by electrochemically silent metals is based on the formation of glutathione conjugates and on their decomposition under physiological conditions to yield two toxic agents: the nano-particulate metal sulphides that deposit in organ parenchyma and the electrophilic dehydroalanine analogue of glutathione

Study Design & Methodology Male Wistar rats (1216 weeks old) were subjected to surgical detachment of the quadriceps muscle from its attachments at the femur and iliac bone

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