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Actinomyces (121, 122), Prevotella (123), Bacteroides (120, 124), EscherichiaShigella (125) are the main species increased, whereas Mycobacterium , Lactobacillus , Enterobacter (123), Deltaproteobacteria , and Clostridiaceae decreased (126), including CB , FP , Clostridium leptum , Clostridium cluster XlVa , Clostridium cluster XlVb , Clostridium cluster XVIII (127)

Mir-153 decreases TMSB4X expression, but a circular RNA called PIP5K1A can inhibit miR153 and thus affect the expression of TMSB4X.[ref] Clinical trials with TB4 peptide supplements: Thymosin beta 4 is available as a full-length peptide that is usually injected or as a fragment of the peptide that is available orally

Although the underlying mechanisms of BA physiology in glucose metabolism remain unknown, many studies have found that BA physiology is altered in T2DM patients 26

Thymosin beta 4 mediates oligodendrocyte differentiation by upregulating p38 MAPK