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This is a concept that Gabor Mate, MD speaks of frequently in his books about trauma and its link to various chronic conditions like autoimmunity

10.1021/cr068000q 34 OkanoG.IgarashiS.YamamotoY.SaitoS.TakagaiY.OhtomoT.et al (2015)

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In a rat acute myocardial infarction model, created by ligating the anterior descending branch of the left coronary artery, catalpol inhibits myocardial cell necrosis and apoptosis by downregulating the receptor-interacting protein-1 (RIP1)/RIP3/MLKL pathway (Li H