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ATF4 resulted in the induction of heat shock protein 70 family protein 5 (HSPA5), which in turn bound GPX4 and protected against GPX4 protein degradation and subsequent lipid peroxidation (Zhu et al., 2017), and GSH-specific gamma-glutamylcyclotransferase 1 (CHAC1) degradation of GSH enhanced ferroptosis through GCN2-eIF2-ATF4-GPX4 pathway (Chen et al., 2017)

Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance

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Namely, proteinprotein and protein-DNA interactions are disrupted by GST tag crosslinking, which results in functional inactivation of the fused protein