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Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension

Growing evidences indicate that the increased production of reactive oxygen species and oxidative stress, a condition occurring when this balance is disrupted by excessive production of reactive oxygen species and/or by inadequate antioxidant defenses, in the brain are among the causative mechanisms of cerebral tissue damage in both ischemic and hemorrhagic strokes

The initial findings of this study emphasized the increased rate of phosphorylated respiration V3 and ADP phosphorylation as well as the increase of the respiratory control ratio

Another important culprit in PD is the activation of platelet and coagulation system induced by the trauma of tunica albuginea (Lucattelli et al., 2008)

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