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72 Intracranial pathological changes of microangiopathy include endothelial dysfunction, platelet aggregation impairment, and increased inflammation

Journal of Molecular Neuroscience 44: 611

Fe 2+ , free iron ions, forms an unstable iron pool (LIP) in cells, which is transferred to mitochondria and participates in the formation of iron-dependent protein complexes, iron-sulfur clusters, heme, and other metabolic processes