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Nutrients 9:120

Reduced peri-infarct astrocyte reactivity in C3a-treated mice was associated with upregulation of Igf1 and Thbs4 , coding for insulin-like growth factor 1 (IGF-1) and thrombospondin-4 (THBS4), respectively, both of which are highly expressed in peri-infarct astrocytes 383

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In addition, EAAT3 is important for the oxidative balance of neurons since it also transports cysteine, a rate limiting component of glutathione, an important component of baseline oxidative balance in neurons [22]