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For example, intranasal insulin has been shown to enhance memory and reduce progression of white matter hyperintensity volume over 12 months, supporting its potential as a BBB-bypass therapeutic via olfactory and trigeminal pathways (Kellar et al., 2021)

Ukr Khim Zh 22:603607 Pfeffer MA, Braunwald E, Moy LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC et al (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial

Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

Grk6 knockdown reduces cellular insulin levels, and attenuates insulin secretion, but enhances proinsulin secretion consistent with decreased processing [138]

Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway