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Nature Communications 14 (1), 7237

Wetherill, Y

Morphological characteristics include reduced volume of mitochondria, increased bilayer density, reduction or absence of mitochondrial ridges, and smaller cells separated from one another (1921), while biochemical characteristics include glutathione depletion, reduced activity of glutathione peroxidase 4 (GPX4), and Fe 2+ which generate large amounts of reactive oxygen species in a Fenton reaction, contributing to lipid peroxidation and causing ferroptosis (22, 23)

Lipoic acid, a potent reducing agent, is considered a universal antioxidant due to its amphipathic nature (both fat- and water-soluble)

doi:10.1056/NEJMoa1905239 Nissen SE, Linnebjerg H, Shen X, et al