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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

For research only !!

Because of its affinity to skin and hair tissue, GHK-Cu is a booming ingredient in many skincare products marketed to aid skin repair, skin firmness, and anti-aging

When intra-portal insulin levels are increased (e.g., obesity, Cushings syndrome, or due to treatment with glucocorticoids and glucagon-like peptide 1 receptor agonists) or decreased (e.g., malnutrition, anorexia nervosa and type 1 diabetes mellitus), these changes secondarily alter hepatic GH sensitivity resulting in a secondary association with discordant GH and IGF-I levels (e.g., high GH/low IGF-I levels or low GH/high IGF-I levels, respectively)

This study was supported by Sistem Modal Insan Bersepadu (SMIP), Faculty of Medicine, Universiti Kebangsaan Malaysia