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Similar to 2-AAPA treatment, knockdown of Glutathione Reductase elevated the GSSG/GSH ratio (Figure S3A) and diminished ER stress signaling (Figure 4A)

Considering the improvement of immunotherapy strategies, inhibition of a single pathway or a single enzyme does not reflect the outstanding potential of targeted fatty acid metabolism in cancer immunotherapy

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Subsequent secondary-source reviews have proposed candidate interactions modulation of GABAergic and glutamatergic tone, possible NMDA-receptor involvement, peripheral 1-adrenergic effects but these have not been replicated in primary studies that establish direct binding or saturable transduction at a defined receptor