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The drug carries risks of dependency because of its amphetamine-like mechanism

The majority of patients (80%) were male and half of the recipients were Hispanic

J Bone Miner Res Off J Am Soc Bone Miner Res

AMPK Activation as the Core Mechanism Berberine activates AMP-activated protein kinase (AMPK) in hepatocytes and skeletal muscle, a pathway that overlaps meaningfully with metformin [5]