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Hu and co-workers also showed that the brain targeting efficiency was impacted by the types of phospholipids used in the preparation of liposomes [47]

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Upregulation or modulation of genes involved in the ergosterol biosynthetic pathway (ERG family), as well as modifications to sterol content, may alter the binding or activity of polyenes, and in the case of azoles, change the abundance of the target enzyme (lanosterol 14-demethylase), which affects its activity